The building of the Guangzhou General Branch of the Qing Dynasty Post Service was constructed in the Guanxu Emperor's rule (1897), during the Qing Dynasty (1644-1911). The Building, then the seat of Guangzhou General Branch of the Qing Dynasty Post Service, burnt to the ground during the first year of the Republic of China (1912). In the next year, the site was allocated by the preparatory office of the Guangdong Provincial National Taxation Department to the Canton Customs to build a new post office. The post office was then designed by a British architect and rebuilt at the original site in 1916.

The post office service was managed by Canton Customs before Guangdong Post Affairs Administration took over in 1918. Japanese troops invaded Guangzhou in 1938 and set fire to the building in Xiti region. The door, windows and floor of the building were all destroyed, although the doorframe survived the fire. The building was again re-designed by Yang Yongtang in 1939, and restored according to the original appearance. The construction of the building was completed in 1942, and has been maintained to the present day.

The building was renovated as the Guangzhou Post Service Museum in May 2002, and it was listed as one of the fourth batch of Guangdong Provincial Cultural Relic Protection Units in July the same year.

Address: No.43 West Yanjiang Road, Liwan district